Registration Dossier
Registration Dossier
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EC number: 483-390-9 | CAS number: 12508-61-1
Endpoint summary
Administrative data
Description of key information
Testing was carried out on the following endpoints using the following guidelines:
Acute toxicity: Oral - OECD Guidelines for the Testing of Chemicals No. 423 “Acute Oral Toxicity – Acute Toxic Class Method” (adopted 17 December 2001).
Acute Toxicity: Dermal - OECD Guidelines for the Testing of Chemicals No. 402 “Acute Dermal Toxicity” (adopted 24 February 1987).
Acute Toxicity: Inhalation was not performed due to the physico-chemical properties of the substance and the exposure scenario of the identified uses.
The above studies have all been ranked reliability 1 according to the Klimisch system. This ranking was deemed appropriate because the studies were conducted to GLP and in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 500 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Testing on the above endpoints gave the following results:
Acute toxicity: Oral.
Mortality: There were no deaths.
Clinical Observations: There were no signs of systemic toxicity.
Bodyweight: All animals showed expected gains in bodyweight over the study period.
Necropsy: No abnormalities were noted at necropsy.
Conclusion: The acute oral median lethal dose (LD50) of the test material in the female Sprague-Dawley CD strain rat was estimated to be greater than 2500 mg/kg bodyweight.
Acute toxicity: Dermal.
Mortality: There were no deaths.
Clinical Observations: There were no signs of systemic toxicity.
Dermal Irritation: There were no signs of dermal irritation.
Bodyweight: All animals showed expected gains in bodyweight over the study period.
Necropsy: No abnormalities were noted at necropsy.
Conclusion: The acute dermal median lethal dose (LD50) of the test material in the Sprague‑Dawley CD strain rat was found to be greater than 2000 mg/kg bodyweight.
Justification for classification or non-classification
The above results triggered no classification under the CLP Regulation (EC No 1272/2008).
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