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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From May 11, 2016 to May 19, 2016
Reliability:
1 (reliable without restriction)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
not specified
Type of method:
flask method
Specific details on test material used for the study:
Batch n° 145
Appearance white granular powder
Key result
Water solubility:
499 000 mg/L
Conc. based on:
test mat.
Incubation duration:
24 h
Temp.:
20 °C
pH:
10.1
Remarks on result:
other: due to the formation of a gel, the investigation was stopped and the water solubility was approximated to 499000 mg/L. It is possible to create a gel with even higher concentrations of the test substance.
Details on results:
With 1.9882 g test substance being mixed into 2 g of water, a gel with a total weight of 3.9882 g was formed. This was equivalent to 49.9% (w/w) of test substance in solution/gel. Due to the fact that the density of the gel is not known and that the formation of the gel is a continuous process and no discrete point can be identified at which dissolution in water switches to gelling, the water solubility could only be approximated to 499000 mg/L. It was possible to create a gel with even higher concentrations of the test substance. The pH value of a 10% solution of the test substance in water was 10.10 and the experiments were performed at 20°C.

Table 1. Amounts of test substance added to water










































Experiment



Water [g]



Weighed sample [g]



Result



A



2.0



0.1032



clear liquid



B



2.0



0.4662



clear liquid



c



2.0



1.1093



clear liquid, viscous



D



2.0



1.9882



gel



E



2.0



3.0456



gel



 

Conclusions:
Under the study conditions, the water solubility of the substance was determined to be 499000 mg/L at 20°C and pH 10.1.
Executive summary:

A study was conducted to determine the water solubility of the substance according to OECD Guideline 105. Increasing amounts of the test substance were weighed and added into the 2 g of water. After the addition of the test substance, the mixtures were shaken or allowed to stand for 24 hours and were visually checked for any undissolved parts of the sample. The pH value of a 10% solution of the test substance in water was 10.1 and the experiments were performed at 20°C. While adding 1.9882 g of test substance into 2 g of water, a gel with a total weight of 3.9882 g was formed. This was equivalent to 49.9% (w/w) of test substance in solution/gel. Due to the fact that the density of the gel is not known and that the formation of the gel is a continuous process and no discrete point can be identified at which dissolution in water switches to gelling, the water solubility could only be approximated to 499000 mg/L. It was possible to create a gel with even higher concentrations of the test substance. Under the study conditions, the water solubility of the substance was determined to be 499000 mg/L at 20°C and pH 10.1 (Schwarzkopf, 2016).

Description of key information

The water solubility was determined according to OECD Guideline 105 and EU Method A.6 (Schwarzkopf 2016)

Key value for chemical safety assessment

Water solubility:
499 000 mg/L
at the temperature of:
20 °C

Additional information