2,4-dihydroxybenzoic acid

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

09.04.2018 - 13.04.2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

Published in O.J. L 142, 2008

Deviations:

no

GLP compliance:

no

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

2,4-dihydroxybenzoic acid

EC Number:

201-946-9

EC Name:

2,4-dihydroxybenzoic acid

Cas Number:

89-86-1

Molecular formula:

C7H6O4

IUPAC Name:

2,4-dihydroxybenzoic acid

Test material form:

solid

Results and discussion

Water solubility

Key result

Water solubility:

5.96 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

>= 2.42 - <= 2.47

Any other information on results incl. tables

Table: Results of determination of test substance solubility in water by flask method

Day	pH of saturated solution	1^stinjection (mg/L)	2^ndinjection (mg/L)	Average of 1^stand2^ndinjection (mg/L)
1^st	2.47	6.04	6.04	6.04
2^nd	2.42	5.88	5.88	5.88
3^rd	2.42	5.96	5.95	5.96
Mean				5.96
SD				0.08
RSD (%)				1.35

 Repeatability of measurement is less than 15 %, the individual results may be averaged.

Applicant's summary and conclusion

Conclusions:

The water solubility of the test substance 2.4-Dihydroxybenzoic acid determined by the flask method is 5.96 g/L.

Executive summary:

The water solubility of beta-resorcylic acid acc. to EU-method A.6 is 5.96 g/L.