Registration Dossier
Registration Dossier
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EC number: 237-731-1 | CAS number: 13951-70-7
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
16Alpha-Hydroxyprednisolone has an effect on Daphnia mobility (60 and 75% immobilisation) after 48 h exposure at 97.8 and 206 mg/L, the highest concentrations employed.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 109 mg/L
Additional information
The acute toxicity of 16Alpha-Hydroxyprednisolone to Daphnia magna was assessed under static exposure conditions, in a new study according to GLP and OECD No 202 guideline.Based on mean measured concentrations, the 48-hour EC50 of 16Alpha-Hydroxyprednisolone for the immobilisation of Daphnia magna was calculated to be 109 mg/L (95% confidence limits of 97.8 and 41.6 mg/L), and the ‘no-observed effect concentration’ of 16Alpha-Hydroxyprednisolone to Daphnia magna was 41.6 mg/L.
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