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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro cytogenicity / chromosome aberration study in mammalian cells
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
07/01/2020
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 473 (In Vitro Mammalian Chromosomal Aberration Test)
GLP compliance:
yes (incl. QA statement)
Type of assay:
in vitro mammalian chromosome aberration test

Test material

Constituent 1
Chemical structure
Reference substance name:
3-(isodecyloxy)propylammonium acetate
EC Number:
249-166-8
EC Name:
3-(isodecyloxy)propylammonium acetate
Cas Number:
28701-67-9
Molecular formula:
C13H29NO.C2H4O2
IUPAC Name:
3-[(8-methylnonyl)oxy]propan-1-aminium acetate
Test material form:
liquid

Results and discussion

Test results
Key result
Species / strain:
Chinese hamster lung (CHL/IU)
Metabolic activation:
with and without
Genotoxicity:
not specified
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
True negative controls validity:
not specified
Positive controls validity:
not specified

Applicant's summary and conclusion

Conclusions:
The prediction indicates that the studied compound is identified as a potential mutagen causing chromosome-type aberrations.

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