Tobacco, ext.

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

not specified

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data is cited in the database as peer reviewed, and recommended in ECHA Guidance on information requirements. Therefore it is considered as reliable, but with restrictions due to lack of details.

Reason / purpose for cross-reference:

reference to other study

Principles of method if other than guideline:

No data

Specific details on test material used for the study:

no data

Key result

Water solubility:

1 000 000 mg/L

Temp.:

25 °C

Remarks on result:

other: PH not reported

Details on results:

pH not specified

No additional information

Conclusions:

Interpretation of results : miscible

Executive summary:

The HSDB database provides, as secondary source, some physico-chemical properties. A water solubility of 100000 mg/L at 25°C is reported for nicotine (no data on purity, nor method, nor pH).

Reference 2

Endpoint:

water solubility

Data waiving:

other justification

Justification for data waiving:

other:

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING:
The test item is a complex substance for which only a part of the composition has been clearly identified due to technical issues. The application of the standards Water solubility determination methods is limited due to technical issues and limited knowledge of composition of the test item.

(1) Considering the nature of this kind of constituents, we anticipate that the composition of the solubilised fraction should be different from the initial composition and that this composition should vary with the loading rate. However due to analytical issues, the composition of the substance (as such or in water) cannot be deeply determined and due to the large part of the unknown composition, we cannot anticipate the behavior of the constituents of the mixture in water.
(2) Determining the water solubility of some « target » peaks detectable by chromatography may be considered. However the water solubility obtained of these « target » peaks would lead to partial results without proof that the toxicity is linked to the target « peaks ». Considering the very complex nature of the test item, the information obtained from testing is considered as not relevant or of practical use for subsequent assessments and therefore conducting the test is waived based on Chapter R.7a, v6.0, July 2017,R.7.17.4, which reports : “for complex substances the information obtained from such testing is not relevant or of practical use, and therefore conducting the test may be waived where the data is irrelevant for subsequent assessments ».

Description of key information

No range of Water solubility representative of the test item can be determined (neither with an experimental approach nor with an estimation approach)

Additional information

Calculated values of Water solubility were provided on known constituents of the substance. However, only a range of Water solubility on a limited part of the composition of the substance can be calculated using QSAR estimations or literature data.Therefore it is considered that no range of Water solubility representative of the whole test item can be determined (neither with an experimental approach nor with an estimation or literature approach).