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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May 19, 2021
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
duplicates instead of triplicates
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
flask method
Key result
Water solubility:
< 5.08 ppb
Incubation duration:
2 h
Temp.:
25 °C
pH:
ca. 7
Remarks on result:
other: based on LOQ

Description of key information

The water solubility was determined to be <5.08 ppb.
According to the directive EC 1272/2008, a poorly soluble substance can be defined as a substance with a solubility of less than 1 mg/L.

Key value for chemical safety assessment

Water solubility:
0.005 mg/L
at the temperature of:
25 °C

Additional information

The most reliable data available to date is the internal study report from Dutta, 2021. It is chosen as the key study. The substance is extremely low soluble in water, with measured value <5.08 ppb at 25 °C corresponding to the detection limit.

Another data point available is the Rausina, 1996 study. A reliability rating of 2 was assigned to this study, according to the criteria of Klimisch, 1997 as it is considered to be a well-conducted non-guideline non-GLP study. Restricted because study lacks detailed information on individual data and the study is a specialized method that was developed due to very limited water solubility and difficulty in analysis.