Sodium zirconium lactate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Justification for type of information:

Performed to reliable standards to assess dust content.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)

Principles of method if other than guideline:

Seiving methods

GLP compliance:

no

Type of method:

sieving

Type of particle tested:

primary particle

Type of distribution:

mass based distribution

No.:

#1

Size:

< 63 µm

Distribution:

ca. 15 %

No.:

#2

Size:

> 63 - < 250 µm

Distribution:

ca. 57 %

No.:

#3

Size:

> 250 µm

Distribution:

ca. 28 %

Conclusions:

Low dust content

Executive summary:

-      Retained by 250 µm = 15.27%

-      Retained by 63 µm =56.68%

-      < 63 µm =28.15%