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Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
no guideline followed

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A solid sample of the cobalt complex (1.3 mg) is added to 5.0 mL of n-octanol (99%) at 20°C. The sample is agitated by shaking. The concentration of the substance in the octanol solution is determined by UV-vis spectroscopic method.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrahydrogen [29H,31H-phthalocyanine-2,9,16,23-tetrasulphonato(6-)-N29,N30,N31,N32]cobaltate(4-)
EC Number:
238-200-7
EC Name:
Tetrahydrogen [29H,31H-phthalocyanine-2,9,16,23-tetrasulphonato(6-)-N29,N30,N31,N32]cobaltate(4-)
Cas Number:
14285-59-7
Molecular formula:
C32H16CoN8O12S4
IUPAC Name:
tetrahydrogen [29H,31H-phthalocyanine-2,9,16,23-tetrasulphonato(6-)-N29,N30,N31,N32]cobaltate(4-)

Results and discussion

Solubility in organic solvents / fat solubility
Key result
Medium:
n-octanol
Solubility:
< 7 mg/L
Temp.:
20 °C
Test substance stable:
yes

Any other information on results incl. tables

The sample was agitated by shaking in an attempt to effect dissolution; however, no dissolution was observed. The sample dissolution experiment was continued for three days with no observed change.

It was not feasible to conduct the octanol dissolution experiment to test for lower levels of solubility due to experimental constraints.

Additionally, the cobalt analyte in n-octanol was not detectable by UV-vis spectroscopic methods. The UV-vis spectroscopic method could detect up to 0.007 g/L in aqueous solution, and it is assumed the extinction coefficient would be similar to n-octanol and water for the analyte. Therefore, this study can only conclude that the solubility of the cobalt complex in n-octanol is less than 0.007 g/L.

Applicant's summary and conclusion

Conclusions:
The solubility of the test item in n-octanol is less than 7 mg/L (LOD of the UV-vis spectroscopic method) at 20°C. In addition, visually no dissolution of this coloured solid is observed.

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