Registration Dossier
Registration Dossier
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EC number: 483-990-0 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- D-xylofuranose oligomeric dodecyl glycosides (degree of polymerisation = 1)
- Molecular formula:
- C15H30O5
- IUPAC Name:
- D-xylofuranose oligomeric dodecyl glycosides (degree of polymerisation = 1)
- Reference substance name:
- D-xylofuranose oligomeric dodecyl glycosides, degree of polymerisation 2
- Molecular formula:
- C20H38O9
- IUPAC Name:
- D-xylofuranose oligomeric dodecyl glycosides, degree of polymerisation 2
- Reference substance name:
- D-xylofuranose oligomeric tetradecyl glycosides (degree of polymerisation = 1)
- Molecular formula:
- C17H34O5
- IUPAC Name:
- D-xylofuranose oligomeric tetradecyl glycosides (degree of polymerisation = 1)
- Reference substance name:
- D-xylofuranose oligomeric tetradecyl glycosides, degree of polymerisation 2
- Molecular formula:
- C20H38O9
- IUPAC Name:
- D-xylofuranose oligomeric tetradecyl glycosides, degree of polymerisation 2
- Reference substance name:
- D-glucopyranose oligomeric dodecyl glycosides, degree of polymerisation 1
- Molecular formula:
- C15H30O5
- IUPAC Name:
- D-glucopyranose oligomeric dodecyl glycosides, degree of polymerisation 1
- Reference substance name:
- D-glucopyranose oligomeric dodecyl glycosides, degree of polymerisation 2
- Molecular formula:
- C20H39O9
- IUPAC Name:
- D-glucopyranose oligomeric dodecyl glycosides, degree of polymerisation 2
- Reference substance name:
- D-glucopyranose oligomeric tetradecyl glycosides, degree of polymerisation 1
- Molecular formula:
- C15H30O5
- IUPAC Name:
- D-glucopyranose oligomeric tetradecyl glycosides, degree of polymerisation 1
- Reference substance name:
- D-glucopyranose oligomeric tetradecyl glycosides, degree of polymerisation 2
- Molecular formula:
- C20H38O9
- IUPAC Name:
- D-glucopyranose oligomeric tetradecyl glycosides, degree of polymerisation 2
- Reference substance name:
- Glucose
- EC Number:
- 200-075-1
- EC Name:
- Glucose
- Cas Number:
- 50-99-7
- Molecular formula:
- C6H12O6
- IUPAC Name:
- D-glucose
- Reference substance name:
- Xylose
- EC Number:
- 200-400-7
- EC Name:
- Xylose
- Cas Number:
- 58-86-6
- Molecular formula:
- C5H10O5
- IUPAC Name:
- Oxane-2,3,4,5-tetrol (D)
- Reference substance name:
- Tetradecanol
- EC Number:
- 204-000-3
- EC Name:
- Tetradecanol
- Cas Number:
- 112-72-1
- Molecular formula:
- C14H30O
- IUPAC Name:
- Tetradecan-1-ol
- Reference substance name:
- Dodecan-1-ol
- EC Number:
- 203-982-0
- EC Name:
- Dodecan-1-ol
- Cas Number:
- 112-53-8
- Molecular formula:
- C12H26O
- IUPAC Name:
- Dodecan-1-ol
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
Constituent 8
Constituent 9
Constituent 10
Constituent 11
Constituent 12
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 2
- Reversibility:
- fully reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 2
- Reversibility:
- fully reversible
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Based on the study, the substance is irritating to the eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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