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Diss Factsheets
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EC number: 828-229-9 | CAS number: 7019-19-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- 2-hydroxyoctanal/1-hydroxyoctan-2-one
- Type of composition:
- legal entity composition of the substance
- State / form:
- liquid
- Reference substance:
- 2-hydroxyoctanal/1-hydroxyoctan-2-one
- PBT status:
- the substance is not PBT / vPvB
- Justification:
PERSISTENCE ASSESSMENT
The biodegradation of 1 -hydroxyoctan-2 -one in an OECD 301F study was 76.8% within 28 days and the substance is considered readily biodegradable meeting the 10d window (see IUCLID Section 5.2.1). Therefore the criteria for 'P' for the PBT / vPvB Assessment is not fulfilled.
BIOACCUMULATION ASSESSMENT
The registered substance 1-hydroxyoctan-2-one was found to have an experimental log Kow value of 1.683 at 20°C and pH ~8.3 (see IUCLID Section 4.7) and therefore a low potential for bioaccumulation and biomagnification is expected. The 'B' criteria for the PBT /vPvB Assessment is not fulfilled.
TOXICITY ASSESSMENT
The acute 48h EC50 value for invertebrates (daphnia magna) exposed to 1-hydroxyoctan-2-one was determined to be 39.1 mg/L (nominal). The 72h EC50 value for algae exposed to 1-hydroxyoctan-2-one was determined to be 105.1 mg/L and 45.53 mg/L based on growth rate and yield, respectively. 72h EC10 values were 39.3 and 17.6 mg/L for effects on growth rate and yield, respectively. The 72h NOEC based on growth rate was determined to be 12.5 mg/l. The registration substance is neither mutagenic, reprotoxic, carcinogenic, germ cell mutagenic nor toxic for reproduction. The registration substance is not classified for chronic health effects. Therefore the 'T' criteria for the PBT / vPvB Assessment is not fulfilled.
- Likely routes of exposure:
Humans: Dermal and Eye
Environment: trace amounts are expected to be released via wastewater effluent discharge(s) from municipal STPs to surface waters
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.