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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Read-across data for a structurally analagous source substance to the registration/target substance. Data from peer reviewed scientific journal. Read-across justification report for acute oral toxicity attached to section 13.

Data source

Reference
Reference Type:
publication
Title:
Monograph on fragrance raw materials, METHYL HEXYL KETONE
Author:
Edited by D. L. J. Opdyke
Year:
1975
Bibliographic source:
Food and Cosmetics Toxicology Volume 13, Issue 6 pp 861,1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As described below
Deviations:
not specified
Principles of method if other than guideline:
The acute oral toxicity study has been performed on rat for the chemical methyl hexyl ketone.
GLP compliance:
no
Test type:
other: not specified
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Octan-2-one
EC Number:
203-837-1
EC Name:
Octan-2-one
Cas Number:
111-13-7
Molecular formula:
C8H16O
IUPAC Name:
octan-2-one
Test material form:
liquid
Specific details on test material used for the study:

- Name of test material: Octan-2-one
- Molecular formula: C8H16O
- Molecular weight: 128.21 g/mol
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
Not available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
Not data available
Statistics:
Not data available

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No data available
Clinical signs:
other: Not data available
Gross pathology:
Not data available
Other findings:
Not data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be >5000 mg/kg when rats were treated with methyl hexyl ketone orally.
Executive summary:

In a acute oral toxicity study, rats were treated with octan-2-one in the concentration of 5000 mg/kg orally. No mortality was observed in treated rats at 5000 mg/kg bw. Therefore, LD50 was considered to be >5000 mg/kg when rats were treated with methyl hexyl ketone orally.