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EC number: 701-308-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Density
- Particle size distribution (Granulometry)
- Vapour pressure
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- Additional physico-chemical information
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
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- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
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- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-03-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 437
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- not signed
Test material
- Reference substance name:
- 2-hydroxy-3-{4-[2-(4-{2-hydroxy-3-[(2-methylprop-2-enoyl)oxy]propoxy}phenyl)propan-2-yl]phenoxy}propyl 2-methylprop-2-enoate
- EC Number:
- 701-308-4
- Cas Number:
- 36425-15-7
- Molecular formula:
- n/a
- IUPAC Name:
- 2-hydroxy-3-{4-[2-(4-{2-hydroxy-3-[(2-methylprop-2-enoyl)oxy]propoxy}phenyl)propan-2-yl]phenoxy}propyl 2-methylprop-2-enoate
- Details on test material:
- Approximately 80% BisGMA
13 % Polymeric methacrylates
Constituent 1
Test animals / tissue source
- Species:
- other: Cow
- Details on test animals or tissues and environmental conditions:
- Eyes from cattles were used same days as they were slaughtered
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent vehicle
- Amount / concentration applied:
- 1122 mg and 2484 mg
- Duration of treatment / exposure:
- Corneas were pre-incubated for 1 hour minimum at 32 C. Exposure time was 10 minutes. After exposure the cornea was rinsed to remove the test substance, and incubated for 2 hours for opacity measurement. The permeability was measured after 90 minutes incubation with sodium flourescein
- Observation period (in vivo):
- Corneas were incubated for 2 hours after exposure for opacity measurement, and 90 minutes for permeability testing
- Number of animals or in vitro replicates:
- 3 eyes for negative, positive, positive on gauze pacth and the test substance, respectively.
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Done after exposure time
- Time after start of exposure:
SCORING SYSTEM: Opacity was measured using an opacitometer (OP-KIT,MC2, Clermont, France)
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Mean Opacity
- Basis:
- mean
- Time point:
- other: 2 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- other: Mean Permeability
- Basis:
- mean
- Time point:
- other: 90 minutes
- Score:
- 0.011
- Max. score:
- 0.015
- Irritant / corrosive response data:
- The In Vitro Irritancy score (IVIS) were calculated to 0.2. According to OECD Guideline 437 a substance has to induce a IVIS more or equal to 55.1 in order to be defined as corrosive or severe irritant. The positive controls induced a IVIS at 147 and 134, respectively, where as the negative control induced a IVIS at 0.0, conclusively the tested substance was similar to the negative control.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Small Vinyl Ester was tested for eye irritating potential and permeability, following OECD Guideline 437. The substance obtained values similar to the negative control, thus Small Vinyl Ester is considered a non irritant.
- Executive summary:
Small Vinyl Ester was tested for eye irritating potential and permeability, following OECD Guideline 437. Data for the negative and positive controls showed validity of the test system. Small Vinyl Ester obtained values for both Opacity and Permeability, similar to the negative control. The obtained In Vitro Irritancy Score (IVIS) was 0.2, whereas according to the OECD Guideline 437, a substance has to obtain a IVIS at 55.1 or more in order to be defined as a corrosive or irritant. In can therefore be concluded that Small Vinyl Ester is not an irritant when tested according to OECD Guideline 437.
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