Registration Dossier

Diss Factsheets

Environmental fate & pathways

Biodegradation in water: screening tests

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

According to Annex XI section 1 of Regulation (EC) No 1907/2006 (REACH) testing of biodegradability is scientifically not justified because there is reliable data substantiating the conclusion that the substance is readily biodegradabiliy.

Key value for chemical safety assessment

Biodegradation in water:
readily biodegradable
Type of water:

Additional information

No data is available on the biodegradability of the reaction mass of L-alanyl-L-tyrosine hydrochloride and potassium chloride. However, information on all relevant individual components indicate that the substance is readily biodegradable.

L-Alanyl-L-tyrosine is utilized by microorgansisms as carbon source for energy production and thus, it is first enzymatically hydrolysed and subsequently its constituents are metabolised. Short peptides were taken up by microorganisms and were subsequently hydrolyzed or as an alternative peptidases were secreted and free amino acids were taken up. The hydrolyzed monomers are both natural occurring free amino acids. L-Alanine is readily biodegradable (see L-alanine registration dossier) and several aqueous aerobic biological screening studies have demonstrated that tyrosine is also readily biodegradable. Also the dipeptide L-alanyl-L-tyrosine is readily biodegradable as shown in an experimental study according to OECD301F.