Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 949-344-1 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Read-across data for the dipeptide L-alanyl-L-tyrosine is provided and used to derive an effect value for the UVCB substance reaction mass of L-alanyl-L-tyrosine hydrochloride and potassium chloride.
The reaction mass of L-alanyl-L-tyrosine hydrochloride and potassium chloride is not classified as skin sensitizer.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No data is available on the skin sensitization potential of the reaction mass of L-alanyl-L-tyrosine hydrochloride and potassium chloride.
The substance consists mainly of the dipeptide L-alanyl-L-tyrosine hydrochloride (38-42%) and potassium chloride (46-50%). Besides these main components only non-hazardous / non-classified amino acids/peptides in small amounts are present (e.g. L-alanine hydrochloride 4-7%). Based on the composition of the substance it can be assumed that the results obtained with the individual main components (L-alanyl-L-tyrosine and potassium chloride) apply likewise to the test material under investigation (reaction mass of L-alanyl-L-tyrosine hydrochloride and potassium chloride). Therefore read-across data for the dipeptide L-alanyl-L-tyrosine is provided and used to derive an effect value for the UVCB substance reaction mass of L-alanyl-L-tyrosine hydrochloride and potassium chloride. No data is available for the other components of the reaction mass. However, both KCl and L-Alanine are toxicologically well characterized and no skin sensitization potential is known.
L-Alanyl-L-Tyrosine (L-Ala-L-Tyr) is classified as inconclusive (based on the absence of a biologically relevant activation of the antioxidant/electrophile responsive element (ARE)-dependent pathway in keratinocytes at test concentrations < 1000 μM) in the KeratinoSens assay.
L-Alanyl-L-Tyrosine (L-Ala-L-Tyr) is classified as negative (no increase in the expression levels of CD86 cell surface marker in the U937 cell line) in the U-Sens™ assay.
Therefore, the reaction mass of L-alanyl-L-tyrosine hydrochloride and potassium chloride is not classified as skin sensitizer.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Read-across data for the dipeptide L-alanyl-L-tyrosine is provided and used to derive an effect value for the UVCB substance reaction mass of L-alanyl-L-tyrosine hydrochloride and potassium chloride.
L-Alanyl-L-Tyrosine (L-Ala-L-Tyr) is classified as inconclusive in the KeratinoSens assay and negative in the U-Sens™ assay. No data is available for the other components of the reaction mass. However, both KCl and L-Alanine are toxicologically well characterized and no skin sensitization potential is known.
Therefore, the reaction mass of L-alanyl-L-tyrosine hydrochloride and potassium chloride is not classified as skin sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
