Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Skin Irritation – minimal irritation for rabbits (OECD 404).
Eye Irritation – minimal irritation for rabbits (OECD 405).

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

As assessed in dermal irritation studies, the registered substance is transiently irritating to the skin. In a study utilizing an occluded patch exposure, the presence of erythema was noted within 4 hours of patch removal and remained present until at least seven days post exposure. The severity of the erythema induced by the registered substance exposure ranged from very slight to severe during this time frame. However, upon removal, signs of irritation subside. The registered substance is also transiently irritating to the eye as assessed in rabbits. Redness was noted in all animals up to 24h post exposure and decreased steadily through 14 days post exposure.

Justification for classification or non-classification

No classification for irritation is indicated according to the general classification and labeling requirements for dangerous substances and preparations (Directive 67-548-EEC) or the classification, labeling and packaging (CLP) regulation (EC) No 1272/2008.

 

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