Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
The experimental start date was 14 May 2019, and the experimental completion date was 16 May 2019.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
Vapour Pressure. March 23, 2006.
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: EC A.4
Version / remarks:
Vapour Pressure. March 04, 2016.
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: isothermal thermogravimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxy-phenyl)methyl]quinuclidin-3-amine
EC Number:
831-973-7
Cas Number:
147116-67-4
Molecular formula:
C32H40N2O
IUPAC Name:
(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxy-phenyl)methyl]quinuclidin-3-amine
Test material form:
solid
Details on test material:
White to off-white powder.
Storage Conditions: At room temperature.

Results and discussion

Vapour pressureopen allclose all
Key result
Test no.:
#1
Temp.:
ca. 20 °C
Vapour pressure:
<= 0 Pa
Key result
Test no.:
#2
Temp.:
ca. 25 °C
Vapour pressure:
<= 0 Pa

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the test item at 20°C (293K) and 25°C (298K) was:
20°C 25°C
[Pa] [mm Hg] [Pa] [mm Hg]
Test item ≤ 8.1^10-8 ≤ 6.1^10-10 ≤ 2.0^10-7 ≤ 1.5^10-9
Note: the vapour pressure of the test item (which was, according to the method, extrapolated to 20°C and 25°C) could be slightly overestimated and is reported as less than or equal to values.
Executive summary:

The vapour pressure of the test item at 20°C (293K) is estrimate to be ≤ 8.1^10-8 Pa and ≤ 2.0^10-7 Pa at 25°C (298K)