Registration Dossier
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EC number: 201-555-3 | CAS number: 84-72-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 25, - July 22, 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Remarks:
- Improved OECD 105 water solubility test design Paul Thomas & Virginie Burosse, CEHTRA Consultancy for Environmental and Human Toxicology and Risk Assessment, Lyon
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- Improved OECD 105 water solubility test design Paul Thomas & Virginie Burosse CEHTRA Consultancy for Environmental and Human Toxicology and Risk Assessment, Lyon
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- flask method
- Key result
- Water solubility:
- 694 mg/L
- Conc. based on:
- act. ingr. (dissolved fraction)
- Loading of aqueous phase:
- 694 mg/L
- Incubation duration:
- 7 d
- Temp.:
- 20.5 °C
- pH:
- 4.43
- Conclusions:
- The determined water solubility of the tested ethylphthalyl ethyl glycolate according to OECD 105 resp. EU A.6 was 694 ± 18 mg/L at 20.5 ± 0.5 °C. The measured pH value was 4.43.
Reference
The results of the determination are given in the following table:
Table
|
|
Ethylphthalyl ethyl glycolate concentration mg/L |
||||
Replicate |
pH-Value |
1 day |
2 days |
3 days |
6 days |
7 days |
A |
4.43 |
559 |
740 |
748 |
660 |
711 |
B |
4.43 |
476 |
652 |
616 |
815 |
676 |
C |
4.43 |
541 |
632 |
744 |
603 |
696 |
Mean (A-C) |
|
525 |
674 |
702 |
693 |
694 |
SD |
|
43 |
57 |
75 |
109 |
18 |
The mean difference between last 3 sampling times was < 15 %.
The test temperatures were 20.5 °C with a difference not greater than 0.5 °C.
The test temperatures were: Min.: 20.0 °C, Max.: 21.0 °C.
Extraordinary observations were not made.
The final result was calculated from the mean of the last replicates A, B and C (7 days).
Mean water solubility (n=3): 694 mg/L
Standard deviation (n=3): 18 mg/L
Coefficient of variation (n=3): 2.6 %
Water solubility: 694 ± 18 mg/L
Description of key information
The determined water solubility of the tested ethylphthalyl ethyl glycolate according to OECD 105 resp. EU A.6 was 694 ± 18 mg/L at 20.5 ± 0.5 °C. The measured pH value was 4.43.
Key value for chemical safety assessment
- Water solubility:
- 694 mg/L
- at the temperature of:
- 20.5 °C
Additional information
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