Registration Dossier
Registration Dossier
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EC number: 208-757-0 | CAS number: 540-80-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- other: database
- Title:
- RTECS_A0802000_Nitrous acid, t-butyl ester
- Author:
- NA
- Year:
- 1 981
- Bibliographic source:
- JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume (issue)/page/year: 5,134,1985
Materials and methods
- Principles of method if other than guideline:
- no guideline
- GLP compliance:
- no
- Test type:
- other: not specified
Test material
- Reference substance name:
- tert-butyl nitrite
- EC Number:
- 208-757-0
- EC Name:
- tert-butyl nitrite
- Cas Number:
- 540-80-7
- Molecular formula:
- C4H9NO2
- IUPAC Name:
- tert-butyl nitrite
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Duration of exposure:
- 7 h
- Remarks on duration:
- 7h/60d intermittent
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- other: TCLo
- Remarks:
- Lowest published toxic concentration
- Effect level:
- 1 000 ppm
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: 7h/ 60d intermittent
- Gross pathology:
- Lungs, Thorax, or Respiration - changes in lung weight
Liver - changes in liver weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels-
dehydrogenases
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The TCLo of the test item in mice was 1000 ppm/7h/60d (intermittent).
- Executive summary:
The TCLo of the test item in mice was 1000 ppm/7h/60d (intermittent).
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