Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Remarks:
intraperitoneal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Principles of method if other than guideline:
no guideline specified
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
tert-butyl nitrite
EC Number:
208-757-0
EC Name:
tert-butyl nitrite
Cas Number:
540-80-7
Molecular formula:
C4H9NO2
IUPAC Name:
tert-butyl nitrite
Test material form:
liquid

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
17 mg/kg bw
Based on:
test mat.
Gross pathology:
Liver: other Changes

Applicant's summary and conclusion

Conclusions:
The intraperitoneal LD50 of the test item in mice was 187 mg/kg.
Executive summary:

The intraperitoneal LD50 of the test item in mice was 187 mg/kg.