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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 2009-04-30 to 2009-06-15
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
Batch No.: 08111121
Purity: 98%
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
< 1
pH:
4
Remarks on result:
other: Temperature unknown
Key result
Type:
log Pow
Partition coefficient:
< 1
pH:
7
Remarks on result:
other: Temperature unknown
Key result
Type:
log Pow
Partition coefficient:
< 1
pH:
10
Remarks on result:
other: Temperature unknown
Details on results:
The test substance was less than that of acetanilide at each of pH 4, 7 and 10, indicating log Pow values of less than 1.0. Whilst it was appreciated that significant hydrolysis may have occurred during testing, there was only one significant peak noted in the chromatograms. It was considered that any potential degradate may also be weakly retained on the column and thus co-elute with the test substance.
Conclusions:
The test substance was found to have a logPow value of less than 1 at each of pH 4, 7 and 10.
Executive summary:

The partition coefficient was examined using high performance liquid chromatography according to OECD Method 117.

The test substance was found to have a logPow value of less than 1 at each of pH 4, 7 and 10.

Description of key information

The test substance was found to have a logPow value of less than 1 at each of pH 4, 7 and 10.

Key value for chemical safety assessment

Log Kow (Log Pow):
1

Additional information

The partition coefficient was examined using high performance liquid chromatography according to OECD Method 117.

The test substance was found to have a logPow value of less than 1 at each of pH 4, 7 and 10.

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