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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Dermal absorption

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Administrative data

dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
This summary data reflects the opinion of the CIR Expert Panel that the data are valid and informative, adding to a weight of evidence approach for the potential of the test substance.

Data source

Reference Type:
Safety Assessment of Pentaerythritol Tetraesters as Used in Cosmetics
Becker LC, Bergfeld WF, Belsito DV., et al.
Bibliographic source:
Int. J. Toxicol 34(Suppl 2): 99S-112S

Materials and methods

Test guideline
according to guideline
other: ECHA Technical Guidance Document R.7a
Version / remarks:
Regulation EC No. 1907/2006
Principles of method if other than guideline:
Paper-based review of existing data
GLP compliance:

Test material

Constituent 1
Chemical structure
Reference substance name:
Fatty acids, C5-9, tetraesters with pentaerythritol
EC Number:
EC Name:
Fatty acids, C5-9, tetraesters with pentaerythritol
Cas Number:
Molecular formula:
C25H44O8 to C41H76O8
Reaction Products of fatty acids C5-C9 linear saturated and pentaerythritol
Specific details on test material used for the study:
Molecular weight: 529
Boiling point: 858 deg C
Vapour pressure: 1.6 x 10^-21 mm Hg at 25 deg C
log Kow: 16.7
Water solubility: 3.4 x 10^-15 g/L at 25 deg C

Results and discussion

Percutaneous absorption
Key result
>= 2 - <= 6 %

Any other information on results incl. tables

There were no experimental data discovered on the toxicokinetics of pentaerythritol tetraesters. However, due to the large size of the molecules and the high Pow of the pentaerythrityl tetra C5 -9 acid esters, it is not expected that these ingredients would penetrate the skin. For example, pentaerythryl tetrapelargonate has a log P > 16.7, a molecular weight > 500 and low solubility, so it is not likely to penetrate the skin. The dermal bioavailability of pentaerythrityl tetra C5 -9 acid esters was 2 -6%, based on a dermal toxicity study in rats.

Applicant's summary and conclusion

An expert committee expects pentaerythrityl tetra C5 -9 acid esters would not penetrate the skin. Typical values would be in the range of 2-6% skin penetration.