3,5-Heptanedione-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl) and 3,5-Heptanedione-1,7-bis(4-hydroxyphenyl) and 3,5-Heptanedione-1,7-bis(4-hydroxy-3-methoxyphenyl)

Skin sensitisation

Administrative data

Endpoint:

skin sensitisation: in vitro

Type of information:

experimental study

Adequacy of study:

key study

Study period:

44 Days

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2012

Report date:

2012

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 406 (Skin Sensitisation)

Deviations:

no

GLP compliance:

yes

Type of study:

guinea pig maximisation test

Test material

Test material information

Constituent 1

Reference substance name:

1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione

EC Number:

900-021-3

Molecular formula:

3,5-Heptanedione-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl) :C20 H22O5, 3,5-Heptanedione-1,7 -bis(4-hydroxyphenyl) : C19H20O4, 3,5-Heptanedione-1,7-bis(4-hydroxy-3-methoxyphenyl) : C21H24O6

IUPAC Name:

1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione

Test material form:

solid: crystalline

Results and discussion

In vitro / in chemico

Results

Key result

Parameter:

other: Maximization Test

Vehicle controls validity:

valid

Negative controls validity:

not specified

Positive controls validity:

not specified

Remarks on result:

no indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:

other: Non Sensitisation

Conclusions:

The Skin sensitisation evaluation by Maximization Test using Guineia pig and confirms it is classified as “Weak Sensitizer" or predicts as “Negative''