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EC number: 457-310-8
CAS number: 127733-97-5
PLATINUM(2+), TETRAAMMINE-, (SP-4-1)-, DIACETATE (9CI)
oral toxicity of tetraammineplatinum(II) diacetate to female rats was
assessed in a study conducted according to OECD Test Guideline 423, and
to GLP. A group of three animals received a single gavage dose of the
test material at 2000 mg/kg bw. A further group of six animals received
a dose of 300 mg/kg bw.
higher dose two animals died and the third was killed for humane reasons
on day 2. Gross pathology of the deceased animals showed effects in the
gastrointestinal tract as well as colour abnormalities of the liver,
brain and pituitary. No mortality or significant signs of toxicity were
observed in any of the animals dosed at 300 mg/kg bw. An
acute oral LD50 value of >300 and < 2000 mg/kg bw was determined in
the results of this acute oral rat study, tetraammineplatinum(II)
diacetate should be classified for acute oral toxicity (category 4)
according to EU CLP criteria (EC 1272/2008).
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