Registration Dossier
Registration Dossier
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EC number: 262-104-4 | CAS number: 60207-90-1
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 Feb 1994 to 15 Mar 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- standard operating procedure SOP 433.1.209 was followed.
- GLP compliance:
- yes
- Medium:
- ethanol
- Temp.:
- 25 °C
- Remarks on result:
- other: completely miscible
- Medium:
- acetone
- Temp.:
- 25 °C
- Remarks on result:
- other: completely miscible
- Medium:
- toluene
- Temp.:
- 25 °C
- Remarks on result:
- other: completely miscible
- Medium:
- n-octanol
- Temp.:
- 25 °C
- Remarks on result:
- other: completely miscible
- Medium:
- other: hexane
- Solubility:
- 47 g/L
- Temp.:
- 25 °C
- Medium:
- ethyl acetate
- Temp.:
- 25 °C
- Remarks on result:
- other: completely miscible
- Medium:
- other: dichloromethane
- Temp.:
- 25 °C
- Remarks on result:
- other: completely miscible
- Test substance stable:
- yes
- Details on results:
- The test substance was completely miscible in all solvents except for hexane (47 g/L). The solubility in hexane has been quoted correct to two significant figures and is the weight of the active ingredient per litre of saturated solution.
- Conclusions:
- The solubility of the test substance tested has been assessed and the test substance was found to be completely miscible in seven different organic solvents. In the eighth solvent, n-hexane, it was found to be soluble at 47g/L.
- Executive summary:
The solubility of test substance has been determined in eight organic solvents. As there is no general method available for the determination of the solubility in organic solvents, a SOP was followed in this study. The solubility of the test substance in seven different organic solvents showed to be completely miscible. In the eighth solvent, n-hexane, it was found to be soluble at 47g/L. The test substance is considered stable in organic solvents.
Reference
Description of key information
The test substance can be considered completely miscible in organic solvents, ie. ethanol, acetone, ethyl acetate, methanol, dichloromethane, toluene and octanol. It was found to be soluble in n-hexane up to 47 g/L, Stulz 1994.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
