Registration Dossier
Registration Dossier
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EC number: 815-855-2 | CAS number: 440667-78-7
PBT assessment
Administrative data
Assessed Substance
- Assessed substance:
- substance itself
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- ethyl (2S)-3-[3,5-diamino-4-(4-methoxyphenoxy)phenyl]-2-acetamidopropanoate
- CAS number:
- 440667-78-7
- Identity:
- L-Tyrosine, N-acetyl-3,5-diamino-O-(4-methoxyphenyl)-, ethyl ester
- Molecular formula:
- C20H25N3O5
- Molecular weight:
- ca. 387.44
Reference
- Name:
- L-Tyrosine, N-acetyl-3,5-diamino-O-(4-methoxyphenyl)-, ethyl ester
- Type of composition:
- boundary composition of the substance
- State / form:
- solid: particulate/powder
- Reference substance:
- L-Tyrosine, N-acetyl-3,5-diamino-O-(4-methoxyphenyl)-, ethyl ester
- PBT status of the assessed substance:
- the substance is not PBT / vPvB
Results of detailed PBT / vPvB assessment
Persistence
Evidence of non-P / non-vP properties
Screening criteria
Criteria based on Annex XIII of REACH
Conclusion
- Conclusion on P / vP properties:
- not P/vP
- Remark:
- Due to the degradation (17% in 10 d) the substance is classified as not readily biodegradable. The classification for "not ultimately biodegradable within 28 days” (19% in 28 d) is also not met.
Bioaccumulation
Evidence of non-B / non-vB properties
Screening criteria
- Not B and not vB based on: Log Kow ≤ 4.5
- Remark:
- The log POW of the substance is 0.9
Criteria based on Annex XIII of REACH
Conclusion
- Conclusion on B / vB properties:
- not B/vB
Toxicity
Evidence of non-T properties
Criteria based on Annex XIII of REACH
- Not T based on:
- EC10 or NOEC ≥ 0.01 mg/L for marine / freshwater organisms (long-term toxicity):
- all Values are above this threshold
- and substance is not classified as carcinogenic (category 1 or 2), mutagenic (category 1 or 2), or toxic for reproduction (category 1, 2 or 3) according to Directive 67/548/EEC or carcinogenic (category 1A or 1B), germ cell mutagenic (category 1A or 1B), or toxic for reproduction (category 1A, 1B or 2) according to Regulation EC No 1272/2008:
- this does apply
- and no other evidence of chronic toxicity, as identified by the classifications T, R48 or Xn, R48 according to Directive 67/548/EEC or specific target organ toxicity after repeated exposure (STOT RE category 1 or 2) according to Regulation EC No 1272/2008:
- this does apply
Evidence of T properties
Conclusion
- Conclusion on T properties:
- not T
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