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Physical & Chemical properties

Particle size distribution (Granulometry)

Administrative data

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution

Test material

Constituent 1
Chemical structure
Reference substance name:
ethyl (2S)-3-[3,5-diamino-4-(4-methoxyphenoxy)phenyl]-2-acetamidopropanoate
Cas Number:
440667-78-7
Molecular formula:
C20H25N3O5
IUPAC Name:
ethyl (2S)-3-[3,5-diamino-4-(4-methoxyphenoxy)phenyl]-2-acetamidopropanoate
Test material form:
solid: particulate/powder

Results and discussion

Particle sizeopen allclose all
Key result
Percentile:
D99
Mean:
1 534.67 µm
St. dev.:
22
Remarks on result:
other: St. dev. relative % to mean value
Key result
Percentile:
D95
Mean:
433.67 µm
St. dev.:
43
Remarks on result:
other: St. dev. relative % to mean value
Key result
Percentile:
D90
Mean:
223.5 µm
St. dev.:
27
Remarks on result:
other: St. dev. relative % to mean value
Key result
Percentile:
D75
Mean:
136.83 µm
St. dev.:
14
Remarks on result:
other: St. dev. relative % to mean value
Key result
Percentile:
D50
Mean:
86.88 µm
St. dev.:
9
Remarks on result:
other: St. dev. relative % to mean value
Key result
Percentile:
D10
Mean:
32.2 µm
St. dev.:
6
Remarks on result:
other: St. dev. relative % to mean value

Applicant's summary and conclusion

Conclusions:
6 independent measurements were performed. The average size (D50) of the substance particles was determined to be 86.9 µm