Registration Dossier
Registration Dossier
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EC number: 404-520-2 | CAS number: 139893-43-9 SIMVASTATIN AMMONIUM SALT
Endpoint summary
Administrative data
Description of key information
The substance attained 27% biodegradation over the 28 day test in a Readily Biodegradable COD study and cannot be termed as readily biodegradable.
In a OECD 314B Simulaton test to assess the Biodegradability of Chemicals in Wastewater B; Biodegradatoin in Activated Sludge the substance was tested in both Biotic and Abiotic Sludge for up to 28 days at 22 °C.
Over the 28 day incubation period the amounts of dissolved CO2 were up
to ≤1.4% AR and the no significant quantity of evolved CO2 detected
after 28 days.
Simvastatin ammonium salt was the major component at all times in the
abiotic sludge and declined from 88.7% AR at 1 hour to 45.8% AR at 28
days. Any unknown components were each ≤5.0% AR.
The DT50 for the degradation of simvastatin ammonium salt in biotic and
abiotic sludge at 22oC was 5.37 and 30.7 days respectively.
Additional information
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