Registration Dossier
Registration Dossier
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EC number: 404-520-2 | CAS number: 139893-43-9 SIMVASTATIN AMMONIUM SALT
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 6th February 1988 to 9th February 1988
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Composition:
99.2% L-654,969, 0.2% lovastatin ammonium salt, 0.2% triol - Details on sampling:
- Water samples were taken from control and test concentrations at 0 and 48 hours
- Details on test solutions:
- Test concentrations:
10, 18, 32, 56, 100, 180, 320, 560 and 1000 mg/L - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna (straus)
- Source: Laboratory culture originating from a strain supplied by IRCHA, France.
- Age at study initiation: Between 6 and 22 hours old
Food: fry fish food (Liquefry R) and a suspension of mixed algae (predominantly Chlorella spp.) - Test type:
- static
- Total exposure duration:
- 48 h
- Hardness:
- 350mg CaCO3/L
- Test temperature:
- 21°C ± 1°C
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass jars holding 200ml of test media.
- No. of organisms per vessel: 20 animals per test concentration
OTHER TEST CONDITIONS
- Photoperiod: 16 h light, 8 h dark
- Test concentrations: 10, 18, 32, 56, 100, 180, 320, 560 and 1000 mg/L - Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 220 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 88 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 320 mg/L
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 32 mg/L
- Conclusions:
- EC50 (48 h) 88 mg/L
- Executive summary:
A 48 hour EC50 test was carried out on test substance L654,969 using Daphnia magna (straus). The test condition were static, and according to OECD Guideline 202 and EEC directive 67/548 Annex V C2.
The resulting EC50 (48 h) is 88 mg/L
Reference
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 88 mg/L
Additional information
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