Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
key study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 427 (Skin Absorption: In Vivo Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 870.7600 (Dermal Penetration)
Deviations:
no
Qualifier:
according to guideline
Guideline:
other:
Deviations:
no

Test material

Constituent 1
Test material form:
solid
Radiolabelling:
yes

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Type of coverage:
semiocclusive

Results and discussion

Percutaneous absorptionopen allclose all
Time point:
8 h
Parameter:
percentage
Absorption:
21.63 %
Time point:
24 h
Parameter:
percentage
Absorption:
33.07 %
Time point:
120 h
Parameter:
percentage
Absorption:
26.39 %
Time point:
8 h
Parameter:
percentage
Absorption:
22.61 %
Time point:
120 h
Parameter:
percentage
Absorption:
27.54 %
Time point:
8 h
Parameter:
percentage
Absorption:
15.41 %
Time point:
120 h
Parameter:
percentage
Absorption:
20.82 %

Applicant's summary and conclusion

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