Registration Dossier
Registration Dossier
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EC number: 429-130-1 | CAS number: 2820-37-3
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 427 (Skin Absorption: In Vivo Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.7600 (Dermal Penetration)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other:
- Deviations:
- no
Test material
- Test material form:
- solid
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Type of coverage:
- semiocclusive
Results and discussion
Percutaneous absorptionopen allclose all
- Time point:
- 8 h
- Parameter:
- percentage
- Absorption:
- 21.63 %
- Time point:
- 24 h
- Parameter:
- percentage
- Absorption:
- 33.07 %
- Time point:
- 120 h
- Parameter:
- percentage
- Absorption:
- 26.39 %
- Time point:
- 8 h
- Parameter:
- percentage
- Absorption:
- 22.61 %
- Time point:
- 120 h
- Parameter:
- percentage
- Absorption:
- 27.54 %
- Time point:
- 8 h
- Parameter:
- percentage
- Absorption:
- 15.41 %
- Time point:
- 120 h
- Parameter:
- percentage
- Absorption:
- 20.82 %
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
