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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experiment start date - 25 February 2003; Experiment end date - 27 February 2003; Study completion date - 06 May 2003.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
calculation method (fragments)
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
Identity: FAT 40810/A
Batch: WP 6/02
Purity: approx. 75 %
Appearance: Solid, dark brownish powder
Expiration date: 12 December 2010
Storage: At room temperature at about 20 °C
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
< -4.5
Temp.:
20 °C
Remarks on result:
other: pH not available
Conclusions:
In conclusion, the partition coefficient, log Pow, of FAT 40810/A was calculated to be <- 4.5.
Executive summary:

Neither the HPLC-method according to OECD Guideline No. 117 nor the flask-shaking method according to OECD Guideline No. 107 were applicable for the determination of the partition coefficient of FAT 40810/A. Thus, the log Pow value for the test item was estimated from its solubility in n-octanol arid in water, respectively. The water solubility of the test item was stated to be 224 g/l. The result was used for the calculation of the partition coefficient. In conclusion, the partition coefficient, log Pow, of FAT 40810/A was calculated to be <-4.5.

Description of key information

Neither the HPLC-method according to OECD Guideline No. 117 nor the flask-shaking method according to OECD Guideline No. 107 were applicable for the determination of the partition coefficient of FAT 40810/A. Thus, the log Pow value for the test item was estimated from its solubility in n-octanol arid in water, respectively. The water solubility of the test item was stated to be 224 g/l. The result was used for the calculation of the partition coefficient. In conclusion, the partition coefficient, log Pow, of FAT 40810/A was calculated to be <-4.5

Key value for chemical safety assessment

Log Kow (Log Pow):
-4.5
at the temperature of:
20 °C

Additional information