1-chloro-4-(n-propoxy)-5-thioxanthen-10-one

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

September 1991

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1991

Report date:

1991

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method B.1 (Acute Toxicity (Oral))

Version / remarks:

no data

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1-chloro-4-(n-propoxy)-5-thioxanthen-10-one

EC Number:

415-890-1

EC Name:

1-chloro-4-(n-propoxy)-5-thioxanthen-10-one

Cas Number:

142770-42-1

Molecular formula:

C16H13ClO2S

IUPAC Name:

1-chloro-4-propoxy-9H-thioxanthen-9-one

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River UK
- Age at study initiation: 7 weeks
- Weight at study initiation: 117-138 g
- Fasting period before study: yes
- Housing: in groups of 5 rats of the same sex
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 8 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-23°C
- Humidity (%): 59%
- Air changes (per hr): 10-15%
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Remarks:

CPTX was prepared at a concentration of 50% w/v in corn oil

Details on oral exposure:

volume :10 ml/kg
Administration using a syringe and plastic catheter

Doses:

5000 mg/kg

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: twice daily for mortality, one daily for clinical signs. bodyweight recorded on Days 1, 8 and 15.
- Necropsy of survivors performed: yes (macroscopic examination)

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD0

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

not determinable due to absence of adverse toxic effects

Mortality:

none

Clinical signs:

other: Pilo-erection within 5 minutes of dosing which remainder for Day 1 in all animals but recovery completed by Day 2

Gross pathology:

No macroscopic abnormalities were observed for animals killed on Day
15.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The acute lethal oral dose to rats of the test item was found to be greater than 5000 mg/kg body weight.

Executive summary:

A study was performed to assess the acute oral toxicity of CPTX to the rat. A group of ten fasted rats (5 males and 5 females) was given a single dose by gavage of the test substance, formulated in corn oil, at a dose level of 5000 mg/kg bw. All animals were killed and examined macroscopically on Day 15 (the end of the observation period). There were no deaths. Clinical signs of reaction to treatment were limited to piloerection and recovery was complete by Day 2. A slightly low bodyweight gain was recorded for one male rat on Days 8 and 15. All other rats achieved anticipated bodyweight gains throughout the study. No abnormalities were recorded at the macroscopic exmination on Day 15. The acute lethal oral dose of CPTX was found to be greated than 5000 mg/kg bw.