Choline hydroxide

Flammability

Link to relevant study record(s)

Reference

Endpoint:

flammability, other

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2008-05-01 to 2008-06-02

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Well-documented GLP-study.

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

no guideline available

Principles of method if other than guideline:

The test item is transferred into a glass reaction vessel. The vessel is heated up to discrete temperature levels and the sample is agitated to allow thermal equilibrium and total vaporisation of the sample to occur. A high voltage (15kV) power supply is used to produce the continuous high-energy (spark) ignition source, observations are then made as to whether upward and outward flame propagation is observed.

GLP compliance:

yes

Table 1: Results for Lower & Upper Flammable Limits

Vapour / air % (v/v)	Sample Quantity (cm^3)	Temperature (°C)	Barometric Pressure (kPa)	Comments
0.2	0.10	75	101.3	Sample does not vaporise
0.3	0.10	100	101.3	Sample does not vaporise - discolours
0.3	0.10	100	101.3	Sample decomposes

The flammable range could not be determined as the sample decomposed.

No explicit testing was performed; however, ignition in contact with air did not occur during testing procedure.

Interpretation of results:

GHS criteria not met

Conclusions:

Although no testing guideline is available, the test procedure is well-documented, compliant with GLP and meets general scientific requirements to assess the flammability of the test item. Therefore, the study was attributed a reliability 1 and so the results can be used to assess the physico-chemical hazards of the test item.
The sample is not considered to be a flammable liquid due to the results obtained for the flammable limits whereby no ignition could be obtained up to beyond the boiling point.

Executive summary:

The flammable limits for the test item were analyzed by observing the evaporized substance when exposed to a high-energy ignition source; no test guideline is available, but testing was performed compliant to GLP and the study is considered to be reliable. The flammable range could not be determined as the sample decomposed. The test item is not considered to be a flammable liquid.

Description of key information

The substance is not considered to be a flammable liquid.

Although the pure substance is a solid, flammability testing and evaluation with respect to pyrophoricity, contact with water and self-heating was done with the aqueous solution according to CLP requirements. The substance is only handled and sold as liquid.

Key value for chemical safety assessment

Flammability:

non flammable

Additional information

The experimental results for flammability testing of Choline base derived in the Key Study were chosen because the study can be considered to be of reliability 1 due to its well-documented performance and compliance to GLP. So, no necessity for further testing is indicated and the existing results can be used to assess the physico-chemical hazards of the test item. The flammable range could not be determined as the sample decomposed.

Consequently, Choline base does not need to be classified as flammable and no physical hazard due to flammable properties can arise from the substance.

 

As supportive information data on self-heating and flammability for choline chloride is provided, as it is expected to have a similar flammability behaviour as pure choline hydroxide.

Justification for classification or non-classification

The substance is not considered to be a flammable liquid. The flammable range could not be determined as the sample decomposed.

Therefore, Choline hydroxide does not need to be classified as flammable.