Registration Dossier
Registration Dossier
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EC number: 200-529-9 | CAS number: 62-33-9
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Inconsistent results
Data source
Reference
- Reference Type:
- publication
- Title:
- Summaries of toxicological data
- Author:
- Yang SS, Chan MS
- Year:
- 1 964
- Bibliographic source:
- Fd. Cosmet. Toxicol. 2, 763-767
Materials and methods
- Objective of study:
- excretion
- Principles of method if other than guideline:
- No data
- GLP compliance:
- no
Test material
- Reference substance name:
- Disodium dihydrogen ethylenediaminetetraacetate
- EC Number:
- 205-358-3
- EC Name:
- Disodium dihydrogen ethylenediaminetetraacetate
- Cas Number:
- 139-33-3
- IUPAC Name:
- disodium dihydrogen 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate
- Details on test material:
- no data
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Details on exposure:
- no data
- Duration and frequency of treatment / exposure:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
300, 600, 3000 mg/kg bw/day (original data 0.5; 1.0; 5.0% of the diet, conversion according to EU risk assessment)
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Details on dosing and sampling:
- no data
- Statistics:
- no data
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- no data
- Details on distribution in tissues:
- no data
- Details on excretion:
- - 82.2% of the ingested 0.5% in diet dose was excreted in urine and feces thereof 99.4% were recovered from feces and 0.6% in urine.
- 44.5% of the ingested 1.0% in diet dose was excreted in urine and feces thereof 98.2% were recovered from feces and 1.8% in urine.
- 45.4% of the ingested 5.0% in diet dose was excreted in urine and feces thereof 97.5% were recovered from feces and 2.5% in urine.
Metabolite characterisation studies
- Details on metabolites:
- no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
