Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Title:
Unnamed
Year:
2008

Materials and methods

Test guideline
Guideline:
OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylresorcinol
EC Number:
210-155-8
EC Name:
2-methylresorcinol
Cas Number:
608-25-3
Molecular formula:
C7H8O2
IUPAC Name:
2-methylbenzene-1,3-diol

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
propylene glycol
Analytical verification of doses or concentrations:
yes
Duration of treatment / exposure:
90d
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 100, 200 and 450 mg/kg/day
Basis:
nominal in diet
No. of animals per sex per dose:
Group size: 17 animals per sex at control and high dose (each 5 for recovery)
12 animals per sex at low and mid dose

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
100 mg/kg bw/day (nominal)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: 90d test

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion