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EC number: 264-120-7 | CAS number: 63393-96-4
- Life Cycle description
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
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- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
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- Toxicological Summary
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- Specific investigations
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- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 Oct - 12 Dec 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (non GLP, test substance not characterized in detail).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- non GLP, test substance not characterized in detail
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Quaternary ammonium compounds, tri-C8-10-alkylmethyl, chlorides
- EC Number:
- 264-120-7
- EC Name:
- Quaternary ammonium compounds, tri-C8-10-alkylmethyl, chlorides
- Cas Number:
- 63393-96-4
- Molecular formula:
- Unspecified
- IUPAC Name:
- Quaternary ammonium compounds, tri-C8-10-alkylmethyl, chlorides
- Details on test material:
- - Physical state: yellowbrown, oily liquid
- Purity test date: not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen
- Fasting period before study: 16 h
- Housing: 5 animals per cage in Makrolon 3 cages
- Diet: Altromin-Haltungsdiät 1324, Fa. Altromin, ad libitum
- Water: tap water, ad libitum
- Acclimation period: 7-8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 25
- Humidity (%): 45 - 60
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- peanut oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20% (g/V) for 2000 mg/kg bw and 2% (g/V) for 200 mg/kg bw
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg - Doses:
- 200, 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations for clinical signs and mortality regularly on day of application and 2 x daily thereafter, weighing was carried out one day before application, on day of application and 2, 7 and 14 days following application
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no substance related death at 200 mg/kg bw, but all animals died at the highest dose of 2000 mg/kg bw
- Mortality:
- Neither female nor male animals died in the 200 mg/kg bw test group. Only one male animal had to be killed after 52 hours, but this was due to mistake during gavage. In the 2000 mg/kg bw test group 4 male animals and all female animals died within the first 30 hours after dosing. The additional male animal died 48 hours after application. Thus, mortality was 100% at 2000 mg/kg bw.
- Clinical signs:
- other: Female animals dosed with 200 mg/kg bw did not show any clinical signs. The one male animal that died due to gavage error showed decreased activity, brownish colored nose, vocalization, diarrhoea, severe reduction of body weight and chromodacryorrhoea but
- Gross pathology:
- For the animals dosed with 200 mg/kg bw no abnormal findings at gross necropsy were detected. 2 male animals dosed with 2000 mg/kg bw showed a severe gaseous distention of the small intestine and all 5 female animals showed a slight to severe gaseous distention of the small intestine and the stomach. 1 female animal had a red discolored glandular stomach and the duodenum filled with liquid. 2 male animals and all 5 female animals showed a severe hydrothorax, 2 male animals had redness of the fundus area and moderate ascites. 1 male animal had a filled small intestine, slight ascites and a slight hypothorax.
Any other information on results incl. tables
Table 1. Table for acute oral toxicity.
Dose |
Toxicological results* |
Duration of clinical signs |
Time of death |
Mortality (%) |
Males |
||||
200 |
1/1/5 |
Day 1 |
--- |
20 |
2000 |
5/5/5 |
Day 1 |
24-48 h |
100 |
Females |
||||
200 |
0/0/5 |
Day 1 |
--- |
0 |
2000 |
5/5/5 |
Day 1 |
24-28 h |
100 |
LD50 = 174 mg/kg bw |
* first number = number of dead animals
second number = number of animals with clinical signs
third number = number of animals usedApplicant's summary and conclusion
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