Registration Dossier
Registration Dossier
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EC number: 606-251-8 | CAS number: 1917-44-8
Endpoint summary
Administrative data
Description of key information
In a limit test with 2000 mg test substance/kg bw according to OECD TG 401 and GLP no mortalities have been observed.
LD50, rat, oral: >2000 mg/kg bw
Key value for chemical safety assessment
Additional information
Acute, oral:
In an acute toxicity study with 5 male and 5 female Tif: RAI f (SPF) rats, the animals were dosed with a limit dose of 2000 mg/kg bw by gavage. The study was conducted according to OECD TG 401 (adopted 1987) and GLP regulations. The animals were checked for mortality and signs and symptoms. Body weights were determined on day 0, 7, and 14 and a gross necropsy was performed at the end of the 14 day observation period.
In both sexes piloerection, hunched posture and dyspnea were observed, but were reversible within 4 -6 days after administration. No mortalities occurred and no findings after necropsy were reported. Thus, an LD50 of >2000 mg/kg bw was deduced.
Acut, inhalation:
No data available.
Acut, dermal:
No data available.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
-No classification required for acute toxicity
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008 (last amended by EC/286/2008 (2011-03-10)):
- Oral route: no classification required
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