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EC number: 201-071-2
CAS number: 77-94-1
Table: Summary of test item-related
findings for ATBC
Intended test item intake (mg/kg bw/day)
Alb/Glob ratio (rel, %)
Males (abs., gram)
Males (rel., %)
Females (abs., gram
Females (rel., %)
Liver (no. affected/10)
Males: Hepatocellular hypertrophy
Females: Hepatocellular hypertrophy
This 13-weeks dietary toxicity study
with acetyl tributyl citrate (ATBC) in Wistar rats was designed as dose
range finding study for a subsequent combined chronic/carcinogenicity
study. In principle, the study was performed according to OECD Guideline
408, but with restricted histopathological organ examinations.
The administration at target doses of 100, 300 and 1000 mg/kg bw/d
resulted in no unscheduled deaths. No test item-related clinical signs
were observed. Treatment-related findings were restricted to slight
changes in clinical biochemistry (males were more affected than females)
and slightly increased liver weights accompanied by minimal
hepatocellular hypertrophy at 1000 mg/kg bw/d. The findings were
considered to be due to hepatic metabolic adaption rather than as sign
of toxicity. The highest dose of 1000 mg/kg bw can be
regarded as NOAEL. The proposed dose levels for a subsequent combined
chronic/carcinogenicity study were 100, 300 and 1000 mg/kg bw/d. It can
be assumed that the same applies to tributyl citrate (CAS 77-94-1) as it
is a near analogue to the test substance acetyl tributyl citrate.
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