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Description of key information

Assessment of acute oral toxicity with SMPO Heavy ends in the rat was conducted according to the Acute Toxic Class Method. The substancewas administered undiluted by oral gavage to two subsequent groups of three female Wistar rats at 2000 mg/kg body weight. No mortality occurred.Lethargy, ventro-lateral recumbency, flat posture, hunched posture, uncoordinated movements, piloerection, ptosis and/or hypothermia were noted for the animals between Days 1 and 4. The body weight gain shown by the animals over the study period was considered to be normal. No abnormalities were found at macroscopic post mortem examination of the animals. The oral LD50 value was >2000 mg/kg body weight.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Assessment of acute oral toxicity with SMPO Heavy ends in the rat was conducted according to the Acute Toxic Class Method (Latour, 2015a). The substance was administered undiluted by oral gavage to two subsequent groups of three female Wistar rats at 2000 mg/kg body weight. Animals were subjected to daily observations and weekly determination of body weight. Macroscopic examination was performed after terminal sacrifice (Day 15). 

No mortality occurred. Lethargy, ventro-lateral recumbency, flat posture, hunched posture, uncoordinated movements, piloerection, ptosis and/or hypothermia were noted for the animals between Days 1 and 4.The body weight gain shown by the animals over the study period was considered to be normal.No abnormalities were found at macroscopic post mortem examination of the animals.

The oral LD50 value of SMPO Heavy ends in Wistar rats was established to exceed 2000 mg/kg body weight.


Justification for selection of acute toxicity – oral endpoint
Key study

Justification for classification or non-classification

According to the Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures (including all amendments), SMPO Heavy ends does not have to be classified and has no obligatory labelling requirement for oral toxicity.

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