2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP compliance and OECD method

Data source

Reference

Reference Type:

other: ECHA inquiry result

Title:

Unnamed

Year:

2013

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: OECD 401

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol)

EC Number:

403-800-1

EC Name:

2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol)

Cas Number:

103597-45-1

Molecular formula:

C41H50N6O2

IUPAC Name:

2-(2H-1,2,3-benzotriazol-2-yl)-6-{[3-(2H-1,2,3-benzotriazol-2-yl)-2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)phenyl]methyl}-4-(2,4,4-trimethylpentan-2-yl)phenol

Test animals

Species:

other: rat, Tif:RAIF(SPF)

Administration / exposure

Vehicle:

other: 0.5%(w/v) carboxy methylcellulose in 0.1%w/v acqueous polysorbate

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

Male:2000 mg/kg bw; Number of animals:5; Number of deaths:0
Femaile: 2000 mg/kg bw; Number of animals:5; Number of deaths:0

Clinical signs:

other: Signs of toxicity related to dose levels: Only common symptoms such as piloerection, hunched posture and dyspnea were observed during the study

Gross pathology:

Effects on organs:
No deviation from normal morphology was observed at autopsy

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU