Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984

Materials and methods

Test guideline
Qualifier:
no guideline available
Guideline:
other: according to Draize test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N6-(1-oxooctyl)-L-lysine
EC Number:
245-854-7
EC Name:
N6-(1-oxooctyl)-L-lysine
Cas Number:
23735-96-8
Molecular formula:
CH3-(CH2)6-CO-NH-(CH2)4-CH(-NH2; -COOH)
IUPAC Name:
(2S)-2-amino-6-octanamidohexanoic acid

Test animals / tissue source

Species:
rabbit
Strain:
other: male albino

Test system

Vehicle:
other: olive oil
Number of animals or in vitro replicates:
3 per group
Details on study design:
Draize test

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Time point:
other: 24 hrs
Score:
2
Remarks on result:
other: see 'irritant/corrosive response data'
Irritant / corrosive response data:
20% suspension; vehicle olive oil 24hrs 48hrs 72hrs 1wk
Mean score non-washout 2.0 0.0 0.0 0.0
Mean score washout 0.0 0.0 0.0 0.0

Irritation level was classified according to 'Kay and Calandra method'

Applicant's summary and conclusion

Interpretation of results:
other: minimal irritating
Conclusions:
The test item was minimal irritating.