Registration Dossier
Registration Dossier
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EC number: 245-854-7 | CAS number: 23735-96-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Guideline:
- other: according to Draize test
- GLP compliance:
- no
Test material
- Reference substance name:
- N6-(1-oxooctyl)-L-lysine
- EC Number:
- 245-854-7
- EC Name:
- N6-(1-oxooctyl)-L-lysine
- Cas Number:
- 23735-96-8
- Molecular formula:
- CH3-(CH2)6-CO-NH-(CH2)4-CH(-NH2; -COOH)
- IUPAC Name:
- (2S)-2-amino-6-octanamidohexanoic acid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: male albino
Test system
- Vehicle:
- other: olive oil
- Number of animals or in vitro replicates:
- 3 per group
- Details on study design:
- Draize test
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Time point:
- other: 24 hrs
- Score:
- 2
- Remarks on result:
- other: see 'irritant/corrosive response data'
- Irritant / corrosive response data:
- 20% suspension; vehicle olive oil 24hrs 48hrs 72hrs 1wk
Mean score non-washout 2.0 0.0 0.0 0.0
Mean score washout 0.0 0.0 0.0 0.0
Irritation level was classified according to 'Kay and Calandra method'
Applicant's summary and conclusion
- Interpretation of results:
- other: minimal irritating
- Conclusions:
- The test item was minimal irritating.
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