Registration Dossier
Registration Dossier
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EC number: 940-733-1 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Repeated Dose Oral 90d – NOAEL >=5000 mg/kg for rats (similar to OECD TG 408)
Repeated Dose Inhalation 90d – NOAEL >= 10400 mg/m3 for rats (similar to OECD TG 413)
Key value for chemical safety assessment
Additional information
Oral: C9-C14 aliphatic, < 2% aromatic hydrocarbon fluids are expected to have a low order of repeated dose toxicity by the oral route of exposure. All tests were performed in a manner similar or equivalent to currently established OECD guidelines. In a repeated dose study where C9-C14 aliphatic, < 2% aromatic hydrocarbon fluids were administered via oral gavage, no signs of toxicity were observed at the maximum experimental dose tested, 5000 mg/kg/day.
Inhalation: In a repeated dose study where C9-C14 aliphatic, < 2% aromatic hydrocarbon fluids were administered via inhalation, no signs of toxicity were observed at 10400 mg/m3. Based on these observations, the repeat inhalation concentration NOAEL is >=10400 mg/m3 (10.4 mg/L) for C9-C14 aliphatic, < 2% aromatic hydrocarbon fluids.
Justification for classification or non-classification
These findings do not warrant the classification of C9-C14 aliphatic, < 2% aromatic hydrocarbons as a repeated dose toxicant under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under the Directive 67/548/EEC for dangerous substances and Directive 1999/45/EC for preparations.
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