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EC number: 695-977-9 | CAS number: 1309955-79-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.425 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.163 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.043 µg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 3.1 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 1.692 mg/kg sediment dw
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.169 mg/kg sediment dw
- Assessment factor:
- 500
- Extrapolation method:
- assessment factor
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 5 mg/kg soil dw
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 2 mg/kg food
- Assessment factor:
- 300
Additional information
All endpoints are based on measured data for di (2 -hydroxypropyl)tallow amine or read-across from di (2 -hydroxyethyl)oleyl amine applying the appropriate assessment factors. The PNEC sediment is both calculated using the equilibrium partition coefficient method and based on the sediment test result available for di (2 -hydroxyethyl)oleyl amine. The test result is used for risk assessment purposes. Also for earthworms the toxicity data is read-across from primary fatty amine ethoxylate di (2 -hydroxyethyl) oleylamine (CAS 25307-17-9). A justification for read-across is included in IUCLID Chapter 13.
All endpoints are based on measured data applying assessment factors.
Conclusion on classification
Ecotoxicity
Aquatic ecotoxicity tests have been performed in standard test media to quantify the intrinsic toxicity for C&L purposes and in natural riverwater to derive the PNECaquatic-bulk to be used for environmental risk assessment purposes. The reasoning why this PNECaquatic-bulk is derived is explained in the next paragraph and in the endpoint summaries of the algae and long term daphnia tests.
Due to intrinsic properties of amine containing cationic surfactants river water ecotoxicity tests deliver more reproducible test results with limited uncertainty. River water has a mitigating effect on ecotoxicity due to sorption of the amines to DOC and suspended matter. For this reason, data obtained under standard test conditions is prefered for classification and labeling purposes. If no data obtained under standard conditions is available the results of tests performed in natural river water can be corrected for the mitigation using a worst-case factor of 10 to the L(E)C50 .
More details on the use of the bulk approach are described in a document attached to IUCLID chapter 13.
Table Available algae, daphnia and fish test results (Klimisch 1 and 2)
PFAPO-T (2-[(2-hydroxypropyl)(C16-18 sat. C18 unsat. alkyl)amino]propan-1-ol, (EC 695-977-9, CAS 1309955-79-0, old CAS 68951-72-4)) | ||||
| nominal
| TWA
| ||
| EC(L)50/L(L)C50 | EC(L)10/NOEC(L) | EC50 | EC10/NOEC |
| (µg/L) | (µg/L) | (µg/L) | (µg/L) |
Algae test (2010) | 273** | 137** |
|
|
Bulk-approach static |
|
|
|
|
Akzo Nobel |
|
|
|
|
(CAS 68951-72-4, old CAS) |
|
|
|
|
Algae test (2022) | 361 | 5.87 | 2.02 | 0.284 |
WAF-approach static |
|
|
|
|
Noack |
|
|
|
|
New CAS no.: 1309955-79-0 |
|
|
|
|
Short term daphnia test (2022) | waived | waived | ||
Acute fish test (2022) | waived |
| waived |
|
Long-term fish (2022) | 19.5 | 5.0 | 16.3 | 4.25 |
Flow-through | overall survival | overall survival | overall survival | |
Noack |
|
|
|
|
New CAS no.: 1309955-79-0 |
|
|
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|
Long-term daphnia test (2012) | 480** | 140** |
|
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Bulk-approach semi-static |
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|
Akzo Nobel | ||||
(CAS 68951-72-4, old CAS) | ||||
Long-term daphnia test (2022) | 1874 | 150 | 48.1 | 7.45 |
WAF approach semi-static | ||||
Noack | ||||
New CAS no.: 1309955-79-0 | ||||
Toxicity to microorganisms (2010) | 169000 | 31550 |
|
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Geerts (2010) |
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3h-ECx |
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(CAS 90367-28-5, old CAS) |
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** figures in bold are based on tests in natural river water. The endpoint value is divided by a factor of 10 as worst-case to correct for the mitigation which might be due to the use of natural river water.
Biodegradability
Di (2 -hydroxypropyl) tallowamine is readily biodegrable.
Bioaccumulation potential
No measured BCF fish is available for the primary fatty amine propoxylates. Standard OECD 305 tests are technically very complicated with substances which are sorbing and easily biodegradable. For two pH conditions valid measured log Kow values are however available as presented in the table below. For allow comparison the by EPIsuite (V4.0) calculated Log Kow for the protonated structures is included in the table.
primary fatty amines propoxylates | Measured Log Kow (at pH 7) | Measured Log Kow (at pH 3 - 4) | Calculated Log Kow (EPIsuite) |
Di (2-hydroxypropyl)hexadecylamine | 5.7 | 3.3 | 3.93 |
Di (2-hydroxypropyl)octadecenylamine | 6.1 | 3.6 | 4.7 |
Di (2-hydroxypropyl)octadecylamine | 6.9 | 4.4 | 4.9 |
Di (2-hydroxypropyl)tallow amine | 6.2 | 3.7 | 4.5 |
The highest log Kow is observed for di (2 -hydroxypropyl)octadecyl amine. For this product a pKa was calculated of 5.73. For di (2 -hydroxypropyl) octadecyl amine also the lowest water solubility of 0.15 mg/L was observed. The measured log Kow value of 6.2 indicates a bioaccumulation potential if this substance would have been a narcotic substance. For polar narcotics like the primary fatty amine propoxylates however there is only limited information on the relationship between log Kow and BCF.
For hexadecyl amine rapid metabilisation in fish is anticipated based on in vitro metabolism test results with this substance (Kmet= 0.152 1/d; Bernard et al., 2006). Based on the structural similarity and ready biodegradability of the primary fatty amine propoxylates also similar metabolisation rates are expected. According to the REACH PBT guidance R.11, evidence of high biotransformation/metabolisation rate in fish may be used to support for arguing for a limited bioaccumulation potential but quantitative thresholds have not been established. The use of QSAR- and mechanistically-based bioaccumulation models is also considered valuable in the overall bioaccumulation assessment process. The BCFBAF model (v3.0) as included in EPIsuite (v4.0) allows the inclusion of metabolism into the BCF calculation but the results of this model should be considered with care as the training set holds only a limited number of substances which can reliably be used to predict the fate of cationic surfactants. With a log Kow of 6.2 the BCFBAF model predicts a BCF of 20880 L/kg wwt without metabolism and 148.6 L/kg wwt with metabolism.
Classification according (Classification, Labeling & Packaging Directive286/2011/EC)
Acute toxicity |
|
| Hazard | M-factor |
EC50 = 16.3 µg/L (TWA, long term fish) |
|
| H400 | 10 |
readily biodegradable |
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|
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Chronic toxicity |
|
| Hazard | M-factor |
EC10 = 4.25 µg/L (TWA, long term fish) |
|
| H410 | 1 |
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