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EC number: 222-492-8 | CAS number: 3495-36-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- A) The study was conducted according to OECD Guideline 107 and US EPA Product Properties Teat Guidelines: OPPTS 830.7550. B) Well-defined information were provided on: 1. Compositional information of the test substance (identity and purity) 2. Test methods used in the study 3. Description of methodologies 4. Test results 5. Definite conclusion
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- < -2.2
- Temp.:
- 25 °C
- pH:
- >= 10 - <= 11
- Details on results:
- Preliminary test results:
The addition of octanol-saturated water and water-saturated octanol to the test substance resulted in complete visually observed dilution of the test substance. The estimated Pow and log Pow were 0.22 and 0.66 respectively.
Equilibration time determination:
Equilibration was achieved by the first sampling interval (1h) during which the test substance concentration in the nominal concentration of 0.0089 mol/L was found to be between 0.0088 and 0.0089 mol/L in the aqueous phase and 0.00004 mol/L in the octanol phase. 6 h was selected as a conservative equilibration period for the definitive test.
Analytical method results:
The measured concentrations of the test substance were between 0.0073 and 0.0075 mol/L in the aq. phase and below 0.00004 mol/L in the organic phase.
The calculated value of log Pow of the test substance was found to be less than -2.20 at 25±1°C. - Conclusions:
- Under the study conditions the log Pow for the test substance at 25±1°C is less than -2.20, therefore the test substance does not show the potential to bioconcentrate from water.
- Executive summary:
A study was conducted to determine n-octanol/water partition coefficient (Pow) of the test substance according to OECD Guideline 107 and EPA OPPTS 830.7550 (flask method), in compliance with GLP. A preliminary test was conducted to determine the approximate solubility of the test substance in octanol-saturated water and water-saturated octanol. A second preliminary test was conducted to determine the equilibrium time to be employed during the definitive test. Definitive test was performed for the determination of n-octanol/water partition coefficient of the test substance. A stock solution of the test substance was prepared in octanol-saturated water to a concentration of 0.00075 mol/L. Water-saturated octanol was added to this stock solution in different ratios (1:5, 1:10 and 1:20) and 12 samples were prepared. The samples were centrifuged after an incubation period of 6 h in a rotary shaker and both the aqueous and the organic layers were analysed for the test item concentration in HPLC. In the first preliminary test addition of octanol-saturated water and water-saturated octanol to the test substance resulted in complete visually observed dilution of the test substance. The estimated Pow and log Pow were 0.22 and 0.66 respectively. In the second preliminary study the equilibration was achieved by the first sampling interval (1h). The data generated by the definitive test indicate that the test substance is highly soluble in the aqueous phase and less soluble in the octanol phase. Under the study conditions the log Pow for the test substance at 25±1°C is less than -2.20, therefore the test substance does not show the potential to bioconcentrate from water (Rondon, 1997).
Reference
Details of preliminary results were as follows:
Cesium Formate weight (g) |
Total volume added to sample (mL) |
Approximate saturation concentration (mol/L) |
Octanol-Saturated Water |
||
0.120 |
0.100 |
6.7 |
0.127 |
0.100 |
7.1 |
0.111 |
0.100 |
6.2 |
Water-Saturated Octanol |
||
0.103 |
0.400 |
1.4 |
0.104 |
0.400 |
1.5 |
0.110 |
0.400 |
1.5 |
Details of equilibration time determination:
Nominal concentration of Cesium Formate in aq. layer (mol/L) |
Incubation period (h) |
Measured concentration of Cesium Formate (mol/L)
Octanol Aq. layer layer |
|
0.0089 |
1 |
0.0088 |
0.000040 |
0.0089 |
2 |
0.0088 |
0.000040 |
0.0089 |
4 |
0.0089 |
0.000040 |
0.0089 |
6 |
0.0089 |
0.000040 |
0.0089 |
8 |
0.0089 |
0.000040 |
0.0089 |
16 |
0.0088 |
0.000040 |
0.0089 |
24 |
0.0088 |
0.000040 |
0.0089 mol/l Stock |
0 |
0.0087 |
0.000040 |
Details of analytical method results:
Nominal concentration of Cesium Formate in aq. layer (mol/L) |
Spiking ratio |
Replicate |
Measured concentration of Cesium Formate (mol/L) Octanol Aq. layer layer layer |
log Pow |
|
0.0075 |
1:5 |
1 |
0.0074 |
0.000040 |
-2.13 |
2 |
0.0073 |
0.000040 |
-2.26 |
||
1:10 |
1 |
0.0074 |
0.000040 |
-2.13 |
|
2 |
0.0073 |
0.000040 |
-2.26 |
||
1:20 |
1 |
0.0074 |
0.000040 |
-2.13 |
|
2 |
0.0075 |
0.000040 |
-2.27 |
||
1:5 |
1 |
0.00074 |
0.000040 |
-1.27 |
|
2 |
0.00074 |
0.000040 |
-1.27 |
||
1:10 |
1 |
0.00074 |
0.000040 |
-1.27 |
|
2 |
0.00078 |
0.000040 |
-1.29 |
||
1:20 |
1 |
0.00074 |
0.000040 |
-1.27 |
|
2 |
0.00080 |
-1.30 |
Description of key information
Solid form: the partition coefficient was determined according to OECD Guideline 107.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -2.2
- at the temperature of:
- 25 °C
Additional information
Solid form: Partition coefficient: log Pow < -2.20 at 25 °C
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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