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Diss Factsheets
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EC number: 222-492-8 | CAS number: 3495-36-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From October 2, 2009 to November 5, 2009
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Water solubility was estimated based on visual conception
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- Acceptable
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- Acceptable
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- > 846 - < 866 g/L
- Temp.:
- 20 °C
- pH:
- 13.6
- Remarks on result:
- other: pH was measured if technically feasible
- Conclusions:
- Under the study conditions, the water solubility of the test substance was determined to be in the range of 84.6 - 86.6% w/w at 20±0.5⁰C by visual assessment.
- Executive summary:
A study was conducted to determine the water solubility of the test substance according to EU method A6 and OECD Guideline 105, in compliacne with GLP. Preliminary study was performed and based on that the concentation for the definitive study was chosen. In definitive study, various concentration in % w/w (80.7, 82.6, 84.6, 86.6, 88.6, 90.7, 92.8, 94.9% w/w) were used. In a preliminary visual experiment, the test substance showed a water solubility >89% w/w. No analysis could be performed due to high solubility producing an unfilterable mixture and thus water solubility was estimated based on visual conception. The 24 h definitive test gave more time to reach concentration equilibrium. Under the study conditions, the water solubility of the test substance was determined to be in the range of 84.6 - 86.6% w/w at 20±0.5⁰C by visual assessment (Fox, 2009).
- Endpoint:
- water solubility
- Type of information:
- not specified
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well conducted and well documented study with reliable results but not run according to GLP.
- Principles of method if other than guideline:
- Method followed unknown, data from technical manual.
- GLP compliance:
- no
- Type of method:
- other: No data
- Key result
- Water solubility:
- ca. 83 other: % w/w
- Temp.:
- 20 °C
- pH:
- >= 10 - <= 11
- Conclusions:
- Under the study conditions the water solubility of the test substance powder was determined to be 83 % w/w at 20°C.
- Executive summary:
A study was conducted to determine the water solubility of the test substance using method from Technical Manual, part A: chemical and physical properties, section A1: chemistry. Under the study conditions the water solubility of the test substance powder was determined to be 83 % w/w at 20°C (Company data, 2008).
Referenceopen allclose all
Preliminary test was conducted with various concentration % w/w (40.8, 50.2, 59.9, 70.2, 79.9, 89.0 %).
For all the samples, a slightly hazy colorless solution with a few black particles, no excess substance.
pH was measured at all concentration solubility was found to be >89% w/w at 20±0.5⁰C.
The standard A6 method was not applicable to this test substance due to indeterminable saturation level produced it was not possible to prepare samples at five times the saturation level (recommended in guideline).
Description of key information
Solid form: the water solubility was determined by:
- visual assessment (no analysis could be performed due to high solubility producing an unfilterable mixture)
- method from Technical manual, Part A: chemical and physical properties, section A1: chemistry
Key value for chemical safety assessment
Additional information
Solid form:
- in the range of 84.6 - 86.6% w/w at 20±0.5⁰C (visual assessment)
- 83 % w/w at 20°C (Technical manual)
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