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EC number: 619-057-3 | CAS number: 94667-33-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in soil
Administrative data
- Endpoint:
- biodegradation in soil: simulation testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 307 (Aerobic and Anaerobic Transformation in Soil)
- GLP compliance:
- yes
- Test type:
- laboratory
Test material
- Reference substance name:
- bis(decyl)(2-hydroxyethyl)methylazanium propanoate
- EC Number:
- 619-057-3
- Cas Number:
- 94667-33-1
- Molecular formula:
- C29 H62 N O4 . C3 H5 O2
- IUPAC Name:
- bis(decyl)(2-hydroxyethyl)methylazanium propanoate
Constituent 1
- Radiolabelling:
- yes
Study design
- Oxygen conditions:
- aerobic/anaerobic
- Soil classification:
- USDA (US Department of Agriculture)
Soil propertiesopen allclose all
- Soil no.:
- #1
- Soil type:
- sand
- % Clay:
- 1.7
- % Silt:
- 11.4
- % Sand:
- 86.9
- % Org. C:
- 0.69
- pH:
- 4.75
- CEC:
- 3.5 meq/100 g soil d.w.
- Soil no.:
- #2
- Soil type:
- loamy sand
- % Clay:
- 7.5
- % Silt:
- 13.7
- % Sand:
- 78.8
- % Org. C:
- 1.61
- pH:
- 5.9
- CEC:
- 7.6 meq/100 g soil d.w.
- Soil no.:
- #3
- Soil type:
- sandy loam
- % Clay:
- 4.7
- % Silt:
- 35.8
- % Sand:
- 59.5
- % Org. C:
- 0.73
- pH:
- 6.41
- CEC:
- 6.5 meq/100 g soil d.w.
- Soil no.:
- #4
- Soil type:
- loam
- % Clay:
- 26.7
- % Silt:
- 42.2
- % Sand:
- 31.1
- % Org. C:
- 1.92
- pH:
- 7.39
- CEC:
- 20.6 meq/100 g soil d.w.
- Parameter followed for biodegradation estimation:
- radiochem. meas.
- Details on experimental conditions:
- For the test system 100 g soil (dry weight) for each sample were used. The biological activity of the soils was checked directly after treatment and at the end of incubation.
All-glass test vessels (300 mL) were filled between 3 and 4 Nov 2016 with 100 g soil (dry substance) and moisturized to 53% WHC on 4 Nov 2016. The soil was stored at 20 °C from the filling date and allowed to equilibrate for at least three days before application.
The flasks were incubated under aerobic conditions, by using an air flow-through system. The system was kept moist with a trap filled with dist. H2O in front of every sample. Each flask was connected to two NaOH traps (2 M, 60 mL) to capture the carbon dioxide and one Tenax® trap for organic volatiles. The first in row NaOH traps were changed on 38 d and 70 d of incubation after a colour change of the phenolphthalein occurred in some samples. Microbial Biomass was determined at the arrival, the start and at the end of the study in samples treated with the same amount of solvent as the treated samples.
Duplicate samples for each test system were worked-up per sampling interval. The entire soil per flask was extracted three times under ambient conditions, followed by a single (until sampling interval 30d) or a triple (beginning with sampling interval 45d) extraction under hot conditions in a microwave oven. A last extraction was performed with acetone under ambient conditions. Extracts with > 5% of AR were combined (at least first three extracts were combined). The combined extracts were analysed for [N-methyl-14C] Bardap 26 and possible transformation products with high performance liquid chromatography (radio-HPLC).
Results and discussion
Half-life / dissipation time of parent compoundopen allclose all
- Key result
- Soil No.:
- #1
- DT50:
- 14.6 d
- Type:
- not specified
- Temp.:
- 20 °C
- Key result
- Soil No.:
- #1
- DT50:
- 28.1 d
- Type:
- not specified
- Temp.:
- 12 °C
- Key result
- Soil No.:
- #2
- DT50:
- 10.9 d
- Type:
- not specified
- Temp.:
- 20 °C
- Key result
- Soil No.:
- #2
- DT50:
- 20.7 d
- Type:
- not specified
- Temp.:
- 12 °C
- Key result
- Soil No.:
- #3
- DT50:
- 16.3 d
- Type:
- not specified
- Temp.:
- 20 °C
- Key result
- Soil No.:
- #3
- DT50:
- 30.9 d
- Type:
- not specified
- Temp.:
- 12 °C
- Key result
- Soil No.:
- #4
- DT50:
- 27.6 d
- Type:
- not specified
- Temp.:
- 20 °C
- Key result
- Soil No.:
- #4
- DT50:
- 52.3 d
- Type:
- not specified
- Temp.:
- 12 °C
- Transformation products:
- yes
- Remarks:
- See attached Robust Study Summary
Identity of transformation products
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- dioxomethane
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 204-696-9]
- CAS number:
- 124-38-9
- Details on transformation products:
- With HPLC method 1 (reverse-phase HPLC) the signal M1 was found up to 42.4%, 21.1%, 22.1 % and 7.3% of AR in the soils Lufa 2.1, Lufa 2.2, Lufa 2.3 and Lufa 2.4, respectively.
HILIC HPLC was used to separate possible metabolites associated with M1 resulting in a separation of one major (M1a) and several minor metabolites (H1-H12 – see section 4.6 for example found in lufa 2.1). The major metabolite M1a reached up to 29.4% and 12.7% of AR in the soils Lufa 2.1 and Lufa 2.2, respectively.
Up to 12 minor transformation products occurred during the incubation period whereas two (H6 and H10) did exceed 5% of AR but less than 10% AR. The identification of the structure for H6 was possible.
Applicant's summary and conclusion
- Conclusions:
- [N-methyl-14C]Bardap 26 degraded under aerobic laboratory conditions, with a typical half-live of 14.6, 10.8, 16.2 and 28.2 days in soil extracts for the soils Lufa 2.1, Lufa 2.2, Lufa 2.3 and Lufa 2.4, respectively.
Metabolite M1a reached up to 29.4% and 12.7% AR in the soils Lufa 2.1 and Lufa 2.2, respectively. Metabolites H6 and H10 were observed at higher than 5% AR but less than 10% AR during the study.
H6 was identified but it was not possible to identify H10.
Up to 12 minor transformation products occurred during the incubation period. - Executive summary:
The mean recoveries for the soils Lufa 2.1, 2.2, 2.3 and 2.4 were within the range of 90.8% – 101.2; 91.0% – 100.4%; 92.3 – 106.3% and 91.9% – 98.4% of the applied radioactivity (AR), respectively (satisfying required recovery range for radiolabelled test item).
The radioactivity in the soil extract of Lufa 2.1, 2.2, 2.3 and 2.4 decreased to a minimum of 37.4%; 13.8%; 16.2% and 10.5% of AR after 120 days of treatment, respectively. However, the amount of total carbon dioxide formed during the study was found in the four soils up to 44.1%, 68.9%, 70.2% and 74.3% of AR after 120 days of incubation.
The amount of non-extractable radioactive residues in the soils ranged between 0.4% 52.5%, 0.8% 48.1%, 0.4% 44.9% and 4.2% 28.4% of AR after 30 days of incubation, respectively, and decreased to values of 11.5%, 11.7%, 9.6% and 13.6% of AR after 120 days of incubation.
The microbial biomass for the soils Lufa 2.1, Lufa 2.2, Lufa 2.3 and Lufa 2.4 was measured at the start and at the end of the study was in the range of 2.2 – 13.7, 19.5 – 32.1, 8.4 – 32.9 and 34.6 – 56.6 mg C/ 100 g dry weight, respectively.
According to Irmer (2017, amended 2019), the DT50 ranged between 10.8-28.2 days and DT90 between 35.9-93.6 days, with a single-first order kinetics assigned as best fit to the data (see table A7.2.1-3 for summary of kinetics).
According to Patterson (2019a), the DT50 ranged between 10.9-27.6 days and DT90 between 36.2-91.7 days, with a single first order kinetics assigned as best fit to the data (see summary table 7.2.1-18 and detailed tables 7.2.1-19- 7.2.1-22).
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