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Diss Factsheets
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EC number: 619-057-3 | CAS number: 94667-33-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Method A6 (modified flask method)
- Deviations:
- no
- Principles of method if other than guideline:
- Solubility was determined up to 250,000 mg/l – this is a commonly accepted limit value to define a substance as highly soluble, e.g. Council Directive 94/37/EC Concerning Placing of Plant Protection Products on the Market, page 69, para 2.7.
Annex V, Method A6 is for the determination of the solubility of substances in water. It is the experience in this laboratory (Huntingdon Life Sciences Ltd.) that this method is generally unsuitable for the determination of substances of high solubility in organic solvents.
For example, the use of five-fold excess of test substance produces an over-saturated solution. In cases of substances of high solubility this simply results in a thick suspension or sludge which is often intractable or difficult to separate. Also, the time taken and method employed to separate the phases can affect the solubility result.
Pre-equilibration at 30ºC is not recommended for substances of high solubility it simply induces instant crystallisation and solidification of the test substance to produce an intractable mass on cooling to the test temperature of 20ºC.
Analysis of test substance over different time periods is not required as a limit value of solubility was determined.
NOTE: Test method A6 is unsuitable for highly soluble substances; simple visual estimation is preferable and more likely to give an accurate answer than using A6 with the inherent problems described above. It is also worth noting that method A6 is wholly inappropriate for totally miscible substances where miscibility can only be proven by incremental addition and observation. - GLP compliance:
- yes
- Key result
- Medium:
- ethanol
- Solubility:
- > 250 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- n-octanol
- Solubility:
- > 250 g/L
- Temp.:
- 20 °C
- Test substance stable:
- yes
- Details on results:
- No data
- Conclusions:
- The study was carried out in accordance with Directive 98/8/EC and Directive 92/69/EEC, Method A.6. A known weight of test substance was shaken with increasing volumes of solvent in a stepwise manner and dissolution was assessed visually. The solubility of Bardap 26 AS is greater than 250 g/l in both ethanediol and octanol. No further testing was required.
- Executive summary:
The study was carried out in accordance with Directive 98/8/EC and Directive 92/69/EEC, Method A.6. A known weight of test substance was shaken with increasing volumes of solvent in a stepwise manner and dissolution was assessed visually. The solubility of Bardap 26 AS is greater than 250 g/l in both ethanediol and octanol. No further testing was required.
Reference
Description of key information
The solubility of Bardap 26 AS is greater than 250 g/l in both ethanediol and octanol.
Key value for chemical safety assessment
- Solubility in organic solvents at 20°C:
- 250 g/L
Additional information
The solubility of Bardap 26 AS is greater than 250 g/l in both ethanediol and octanol. No further testing was required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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