Registration Dossier
Registration Dossier
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EC number: 206-991-8 | CAS number: 409-21-2
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Silicon carbide is practically insoluble in water and the substance is unlikely to cross biological membranes. Nevertheless a toxicity test with Daphnia has been performed.Silicon carbide is practically insoluble in water and the substance is unlikely to cross biological membranes. Nevertheless a toxicity test with Daphnia has been performed.
The 22-day NOEC was determined to be >= 100 mg SiC/L for the survival of the adult Daphnia. The 22-day LOEC was determined to be 100 mg SiC/L for the reproduction rate since a statistical significance to the control was observed. With exception of the reduced reproduction rates, no particular signs of intoxication were observed at the test animals during the test.
Due to the low water solubility of the test item the concentration of the test item in the filtrate was below the limit of quantification of the analytical method.
The observed difference in the reproduction rate is only very slight until day 19. Perhaps the significant difference at day 22 on the reproduction is just the result of a slight effect on the date of the reproduction. Additionally the comparison with last 15 finalised Daphnia reproduction studies performed at the test facility demonstrates the value of the alive offspring per adult in the control of the current test appeared to be unusual high. Therefore the result of the study appears to be a pseudo-effect, caused by unusual high reproductive activity in the control treatment of the study. SiC is considered to have no adverse effect on the reproduction of Daphnia magna.
Key value for chemical safety assessment
Additional information
Silicon carbide is practically insoluble in water and the substance is unlikely to cross biological membranes. Nevertheless a toxicity test with Daphnia has been performed.
The 22-day NOEC was determined to be >= 100 mg SiC/L for the survival of the adult Daphnia. The 22-day LOEC was determined to be 100 mg SiC/L for the reproduction rate since a statistical significance to the control was observed. With exception of the reduced reproduction rates, no particular signs of intoxication were observed at the test animals during the test.
Due to the low water solubility of the test item the concentration of the test item in the filtrate was below the limit of quantification of the analytical method.
The observed difference in the reproduction rate is only very slight until day 19. Perhaps the significant difference at day 22 on the reproduction is just the result of a slight effect on the date of the reproduction. Additionally the comparison with last 15 finalised Daphnia reproduction studies performed at the test facility demonstrates the value of the alive offspring per adult in the control of the current test appeared to be unusual high. Therefore the result of the study appears to be a pseudo-effect, caused by unusual high reproductive activity in the control treatment of the study. Hence, SiC is considered to have no adverse effect on the reproduction of Daphnia magna.
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