Penta-1,3-diene

Endpoint summary

Additional information

Very few experimental data on acute toxicity ofpenta-1,3-dieneinclude studies by inhalation performed in rodents. These data are, generally, well above the threshold for classification ofpenta-1,3-dienefor acute toxicity (i.e. >20 mg/L via inhalation exposure routes).

 

QSARs modeling data based on the Cramer method (Estimation of toxic hazard- a decision tree approach) suggests low acute toxicity ofpenta-1,3-diene. Particularly, when concluding the low acute toxicity ofpenta-1,3-diene, the model assumes thatpenta-1,3-dieneis:

 

·                   Simply branched aliphatic hydrocarbon; and

·                   It does not contain any functional groups associated with enhanced toxicity; and

·                   Does not contain elements other than C, H, O, N, divalent S.

 

There are no data on acute toxicity ofpenta-1,3-dienein humans.

 

Given, that penta-1,3-dieneis used in industry for a long time, the lack of reports on serious adverse acute toxicity effects (e.g., death) ofpenta-1,3-dienesupport the low acute toxicity ofpenta-1,3-diene.

 

In conclusion,penta-1,3-dieneis considered to be of low acute toxicity.