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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Additional information

Very few experimental data on acute toxicity ofpenta-1,3-dieneinclude studies by inhalation performed in rodents. These data are, generally, well above the threshold for classification ofpenta-1,3-dienefor acute toxicity (i.e. >20 mg/L via inhalation exposure routes).


QSARs modeling data based on the Cramer method (Estimation of toxic hazard- a decision tree approach) suggests low acute toxicity ofpenta-1,3-diene. Particularly, when concluding the low acute toxicity ofpenta-1,3-diene, the model assumes thatpenta-1,3-dieneis:


·                   Simply branched aliphatic hydrocarbon; and

·                   It does not contain any functional groups associated with enhanced toxicity; and

·                   Does not contain elements other than C, H, O, N, divalent S.


There are no data on acute toxicity ofpenta-1,3-dienein humans.


Given, that penta-1,3-dieneis used in industry for a long time, the lack of reports on serious adverse acute toxicity effects (e.g., death) ofpenta-1,3-dienesupport the low acute toxicity ofpenta-1,3-diene.


In conclusion,penta-1,3-dieneis considered to be of low acute toxicity.

Justification for classification or non-classification